Synthesis

A new approach to the synthesis of polyfunctionally substituted 1, 8-naphthyridin-2-one derivatives from 6-azidopyridones: A novel thermal decomposition to 6- …

RA Mekheimer

Index: Mekheimer Synthesis, 2001 , # 1 p. 103 - 107

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Citation Number: 16

Abstract

Abstract: Azidation of the chloroaldehyde 2, which was obtained from the 6-hydroxy-2- pyridones 1, afforded the 6-azido-2-pyridones 3. Compound 3 can be converted to the corresponding 6-amino-2-pyridones 5, by the reaction with triphenylphosphine via phosphazenes and subsequent hydrolysis (Staudinger reaction). This obtained amine 5 reacts with ethyl cyanoacetate in an ethanolic solution containing piperidine to give 7- ...