ppGpp analogues inhibit synthetase activity of Rel proteins from Gram-negative and Gram-positive bacteria

E Wexselblatt, J Katzhendler, R Saleem-Batcha…

Index: Wexselblatt, Ezequiel; Katzhendler, Jehoshua; Saleem-Batcha, Raspudin; Hansen, Guido; Hilgenfeld, Rolf; Glaser, Gad; Vidavski, Roee R. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 12 p. 4485 - 4497

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Citation Number: 17

Abstract

A prominent feature of the stringent response is the accumulation of two unusual phosphorylated derivatives of GTP and GDP (pppGpp: 5′-triphosphate-3′-diphosphate, and ppGpp: 5′-3′-bis-diphosphate), collectively called (p) ppGpp, within a few seconds after the onset of amino-acid starvation. The synthesis of these 'alarmone'compounds is catalyzed by RelA homologues. Other features of the stringent response include inhibition ...