Synthesis and antibacterial activity of pleuromutilin derivatives with novel C (14) side chain

LQ Fu, CY Ling, XS Guo, HL He, YS Yang

Index: Fu, Li Qiang; Ling, Chen Yu; Guo, Xing Sheng; He, Hui Li; Yang, Yu She Chinese Chemical Letters, 2012 , vol. 23, # 1 p. 9 - 12

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Citation Number: 3

Abstract

In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance, a series of pleuromutilin derivatives with novel C (14) side chain were synthesized and evaluated for their in vitro antibacterial activities. The results of antibacterial acticities indicated that most of the derivatives showed potent activities against Gram- positive organisms. In particular, compound 10d exhibited the most potent inhibitory ...