2??Azabicyclo [2.2. 1] heptane??3??carboxylic acid??A bicyclic proline

DE Gaitanopoulos, J Weinstock

Index: Gaitanopoulos, Dimitri E.; Weinstock, Joseph Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 957 - 959

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Citation Number: 16

Abstract

Abstract Diels-Alder reaction of cyclopentadiene and methyl N-carbobenzyloxy-2- iminoacetate generated in situ from methyl 2-chloro-N-carbobenzyloxyglycinate by triethylamine gave the N-carbobenzyloxy unsaturated bicyclic proline ester. This was converted in two steps to 2-azabicylo [2.2. 1] heptane-3-carboxylic acid. In contrast to N- carbobenzyloxy-L-proline methyl ester, the corresponding bicyclic proline ester was ...

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