Archiv der Pharmazie

Synthesis and Anticonvulsant Properties of New Mannich Bases Derived from 3, 3??Disubstituted Pyrrolidine??2, 5??diones. Part IV

J Obniska, I Chlebek, K Kamiński

Index: Obniska, Jolanta; Chlebek, Iwona; Kaminski, Krzysztof Archiv der Pharmazie, 2012 , vol. 345, # 9 p. 713 - 722

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Citation Number: 6

Abstract

Abstract A library of 21 new N-Mannich bases of 3, 3-diphenyl-(5a–g), 3-methyl-3-phenyl- (6a–g), and 3-ethyl-3-methylpyrrolidine-2, 5-diones (7a–g) were synthesized and evaluated for their anticonvulsant activity in the maximum electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure tests after intraperitoneal injection into mice. The acute neurological toxicity was determined applying the rotarod screen. The results in mice ...