Tetrazoles: XLVI. Alkylation of 5-substituted tetrazoles with methyl chloromethyl ether and α-methylstyrene

LV Myznikov, TV Artamonova, GI Koldobskii…

Index: Myznikov; Artamonova; Koldobskii; Hrabalek Russian Journal of Organic Chemistry, 2004 , vol. 40, # 4 p. 551 - 554

Full Text: HTML

Citation Number: 4

Abstract

Abstract Alkylation of 5-aryl (hetaryl) tetrazoles with methyl chloromethyl ether under conditions of phase-transfer catalysis leads to formation of isomeric 1-and 2- methoxymethyltetrazoles at a ratio of~ 1: 2. The reaction of 5-substituted tetrazoles with α- methylstyrene in the presence of trichloroacetic acid gives the corresponding 2-(α, α- dimethylbenzyl) tetrazoles in high yield and with high regioselectivity.