Angewandte Chemie International Edition

Highly Reactive, Single??Component Nickel Catalyst Precursor for Suzuki–Miyuara Cross??Coupling of Heteroaryl Boronic Acids with Heteroaryl Halides

S Ge, JF Hartwig

Index: Ge, Shaozhong; Hartwig, John F. Angewandte Chemie - International Edition, 2012 , vol. 51, # 51 p. 12837 - 12841 Angew. Chem.

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Citation Number: 60

Abstract

The Suzuki–Miyaura (SM) cross-coupling reaction is the most frequently conducted catalytic process to construct CÀC bonds in medicinal chemistry,[1] and these coupling reactions are conducted most frequently with palladium catalysts.[2] The replacement of the precious metal palladium with the firstrow, abundant metal nickel for SM couplings could significantly reduce the cost of the catalyst. SM couplings catalyzed by nickel complexes, because of ...