Licofelone–nitric oxide donors as anticancer agents
…, J Zhou, Y Liu, H Liu, K Bensdorf, C Guo…
Index: Liu, Wukun; Zhou, Jinpei; Liu, Yinglin; Liu, Haoran; Bensdorf, Kerstin; Guo, Cancheng; Gust, Ronald Archiv der Pharmazie, 2011 , vol. 344, # 8 p. 487 - 493
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Citation Number: 9
Abstract
Abstract Five licofelone ([2, 2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2, 3-dihydro-1H- pyrrolizin-5-yl] acetic acid) nitric oxide donor conjugates were developed by a parallel synthesis approach. The biological screening revealed that compounds with a propyl (6b), butyl (6c), or octyl (6d) chain between licofelone and the nitric oxide donor exhibited high antiproliferative potency at MCF-7 and MDA-MB–231 breast cancer as well as at HT-29 ...
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