Total synthesis of distamycin A and 2640 analogues: a solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents and …

DL Boger, BE Fink, MP Hedrick

Index: Boger, Dale L.; Fink, Brian E.; Hedrick, Michael P. Journal of the American Chemical Society, 2000 , vol. 122, # 27 p. 6382 - 6394

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Citation Number: 191

Abstract

The development of a solution-phase synthesis of distamycin A and its extension to the preparation of 2640 analogues are described. Thus, solution-phase synthesis techniques with reaction workup and purification employing acid/base liquid-liquid extractions were used in the multistep preparation of distamycin A (8 steps, 40% overall yield) and a prototypical library of 2640 analogues providing intermediates and final products that are ...