Tetrahedron letters

Metelation of diazines VIII metalation of 4-chloropyrimidine derivatives new synthesis of trimethoprim

N Plé, A Turck, P Martin, S Barbey, G Quéguiner

Index: Ple; Turck; Martin; Barbey; Queguiner Tetrahedron Letters, 1993 , vol. 34, # 10 p. 1605 - 1608

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Citation Number: 28

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A new synthesis of trimethoprim is described, metalation of a pyrimidine has been used in the key step. An exceptional regioselectivity in the metalation of pyrimidine derivatives has been highlighted. ... A new synthesis of Trimethoprim is described, metalation of a pyrimidine ...