Synthetic communications

An efficient one-pot synthesis of N-methoxy-N-methylamides from carboxylic acids

M Kim, H Lee, KJ Han, KY Kay

Index: Kim, Misoo; Lee, Hagyoung; Han, Ki-Jong; Kay, Kwang-Yol Synthetic Communications, 2003 , vol. 33, # 23 p. 4013 - 4018

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Citation Number: 9

Abstract

Abstract Several N-methoxy-N-methylamides were prepared by the reaction of the corresponding carboxylic acids with N, O-dimethylhydroxylamine hydrochloride at room temperature using trichloromethyl chloroformate in the presence of triethylamine in excellent yields.

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