Dialkyl Barbituric Acids

HA Shonle, AK Keltch, EE Swanson

Index: Shonle; Keltch; Swanson Journal of the American Chemical Society, 1930 , vol. 52, p. 2443

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Citation Number: 22

Abstract

Nearly a hundred different 5, 5-disubstituted barbituric acid derivatives have been prepared in the quarter of a century since Fischer and Dilthey'and Fischer and von Mering* found that certain of these derivatives could be used therapeutically as sedatives and hypnotics. These investigators were aware that certain of the compounds were more active as hypnotics than others and that the effect could be markedly changed by varying the chemical nature of ...