Elaboration of the oxazepine ring system via CuI/L-proline-catalyzed intramolecular aryl amination

L Guo, B Li, W Huang, G Pei, D Ma

Index: Guo, Lei; Li, Ben; Huang, Wenlong; Pei, Gang; Ma, Dawei Synlett, 2008 , # 12 p. 1833 - 1836

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Citation Number: 5

Abstract

As shown in Scheme [³] , we started our attempts by modification of the preparation of cyclization precursors. We found that etherification by directly using 2-aminophenol could proceed smoothly in a mixed solvent at 0 ˚C to afford 3a in 81% yield. [8] This success allows further shortening of the previous five-step procedure to two steps because reduction of nitro group was omitted. Next, we explored the possible reaction conditions for CuI/l-proline-catalyzed ...