Journal of the American Chemical Society

2-(Tributylstannyl)-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzyl alcohol: a building block for photolabeling and crosslinking reagents of very high specific radioactivity

T Weber, J Brunner

Index: Weber, Thomas; Brunner, Josef Journal of the American Chemical Society, 1995 , vol. 117, # 11 p. 3084 - 3095

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Citation Number: 89

Abstract

Abstract: A general approach for the synthesis of novel, radioiodinated photolabeling and cross-linking reagents at no-carrier-added (nca) specific radioactivity (> 2000 Ci/mmol) is described. In this approach, 2-(tributylstanny1)-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzyl alcohol 12 serves as a module which, through acylation of its alcohol function, is connected to other structuraVfunctional elements to make the tin-containing precursor forms of the ...