A novel modification of the Ritter reaction using trimethylsilyl cyanide
HG Chen, OP Goel, S Kesten, J Knobelsdorf
Index: Chen; Goel; Kesten; Knobelsdorf Tetrahedron Letters, 1996 , vol. 37, # 45 p. 8129 - 8132
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Citation Number: 28
Abstract
A new modification of the Ritter reaction using trimethylsilyl cyanide (Me3SiCN) is described, which converts alcohols to their corresponding formamides in high yields using a convenient procedure. The reaction conditions and mechanism are discussed. In some cases, new formamides are synthesized which cannot be prepared by the classical Ritter reaction.
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