2-Substituted aminopyrido [2, 3-d] pyrimidin-7 (8 H)-ones. Structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity

SR Klutchko, JM Hamby, DH Boschelli…

Index: Journal of Medicinal Chemistry, , vol. 41, # 17 p. 3276 - 3292

Full Text: HTML

Citation Number: 150

Abstract

... Journal of Medicinal Chemistry. ... Departments of Chemistry, Cancer Research, Vascular and Cardiac Diseases, and Pharmacokinetics and Drug Metabolism, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor ...

Related Articles:

Application of β-(2-Chloroaroyl) thioacetanilide in Synthesis (III): An Efficient Three-Component Synthesis of Thiochromeno [2, 3-b] pyridines Catalyzed by KF/Neutral …

[Blass, Benjamin E.; Coburn, Keith; Fairweather, Neil; Sabat, Mark; West, Laura Tetrahedron Letters, 2006 , vol. 47, # 18 p. 3177 - 3180]

2-Substituted aminopyrido [2, 3-d] pyrimidin-7 (8 H)-ones. Structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity

[Klutchko, Sylvester R.; Hamby, James M.; Boschelli, Diane H.; Wu, Zhipei; Kraker, Alan J.; Amar, Aneesa M.; Hartl, Brian G.; Shen, Cynthia; Klohs, Wayne D.; Steinkampf, Randall W.; Driscoll, Denise L.; Nelson, James M.; Elliott, William L.; Roberts, Billy J.; Stoner, Chad L.; Vincent, Patrick W.; Dykes, Donald J.; Panek, Robert L.; Lu, Gina H.; Major, Terry C.; Dahring, Tawny K.; Hallak, Hussein; Bradford, Laura A.; Showalter, H. D. Hollis; Doherty, Annette M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3276 - 3292]

A facile, KF/Al 2 O 3 mediated method for the preparation of functionalized pyrido [2, 3-d] pyrimidin-7 (8H)-ones

[Tetrahedron Letters, , vol. 47, # 18 p. 3177 - 3180]

Structure–activity relationships for 2-anilino-6-phenylpyrido [2, 3-d] pyrimidin-7 (8H)-ones as inhibitors of the cellular checkpoint kinase Wee1

[Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 7 p. 1931 - 1935]

More Articles...