Tetrahedron letters

Synthesis of bivalent ligands of β-carboline-3-carboxylates via a palladium-catalyzed homocoupling process

W Yin, PVVS Sarma, J Ma, D Han, JL Chen, JM Cook

Index: Yin, Wenyuan; Sarma, P. V. V. Srirama; Ma, Jun; Han, Dongmei; Chen, Jessica L.; Cook, James M. Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6363 - 6368

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Citation Number: 18

Abstract

The first synthesis of bivalent ligands of β-carboline-3-carboxylates has been achieved from β-carboline-3-carboxylate tert-butyl ester (βCCt) via Sonogashira and palladium-catalyzed homocoupling processes. The Boc protected intermediate, an iodo-β-carboline-3- carboxylate, was employed to provide a general entry into a series of bivalent ligands structurally similar to βCCt.