Isomeric monomethyl ether derivatives of (RS)-9, 10-dihydroxyaporphine (" isoapomorphine") as possible products of metabolism by catechol-O-methyltransferase

JG Cannon, P Qijie

Index: Cannon, Joseph G.; Qijie, Pang Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1079 - 1082

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Citation Number: 4

Abstract

The isomeric monomethyl ether derivatives of (RS)-9, 10-dihydroxyaporphine (“isoapomorphine”) were synthesized unequivocally as possible metabolites in catechol-0- methyltransferase (COMT) mediated 0-methylation reactions. In vitro incubation studies revealed that isoapomorphine is not a substrate for the COMT using experimental conditions under which apomorphine (10, ll-dihydroxyaporphine) is converted in high yield into its 10 ...