Novel benzamides as selective and potent gastric prokinetic agents. 1. Synthesis and structure-activity relationships of N-[(2-morpholinyl) alkyl] benzamides

…, T Kon, S Naruto, N Yoshida, T Karasawa…

Index: Kato; Morie; Hino; Kon; Naruto; Yoshida; Karasawa; Matsumoto Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1406 - 1413

Full Text: HTML

Citation Number: 35

Abstract

release from the cholinergic nerves of the gut. 2 Acetylcholine release is due to either blockade of the serotonin (5-HT3) 3 receptors4* or activation of particular 5-HT-like receptors which have not yet been characterized in the enteric nervous system.'This mechanism of action, however, remains to be determined. On the other hand, metoclopramide has a dopamine D2 receptor antagonistic property, which is not related to ...