Tetrahedron Letters

Design and synthesis of a multi-detachable benzhydrylamine-resin for solid phase peptide synthesis

JP Tam, RD DiMarchi, RB Merrifield

Index: Tam, James P.; DiMarchi, Richard D.; Merrifield, R. B. Tetrahedron Letters, 1981 , vol. 22, # 30 p. 2851 - 2854

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Citation Number: 25

Abstract

Abstract Peptides with C-terminal α-carboxamides were synthesized from a multi-detachable benzhydrylamine-resin containing a Boc-(4-acetoxy) benzhydryl-amine handle of unambiguous origin. The peptides bound to the new resin are stable to trifluoroacetic acid, but are cleavable by hydrogen fluoride, base and nucleophiles to give unprotected or protected peptide fragments.