First total synthesis of the phenolic 7, 8-Dihydro-8-oxoprotoberberine alkaloid, cerasonine
TN Le, WJ Cho
Index: Le, Thanh Nguyen; Cho, Won-Jea Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 7 p. 1026 - 1029
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Citation Number: 14
Abstract
First total synthesis of the phenolic protoberberine, cerasonine, was accomplished through a coupling reaction between o-toluamide and benzonitrile. This key step provided the 3- arylisoquinoline which was then successfully converted to 7, 8-dihydro-8-oxoprotoberberine
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