Synlett

Synthesis of 5-acylindoles via regioselective acylation of 3-trifluoroacetylindole

J Li, B Li, X Chen, G Zhang

Index: Li, Jun; Li, Bogang; Chen, Xiaozhen; Zhang, Guolin Synlett, 2003 , # 10 p. 1447 - 1450

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Citation Number: 2

Abstract

Abstract 5-Acylindoles were synthesized by regioselective acylation of 3-trifluoroacetylindole with acyl chloride under the catalysis of Lewis acids, followed by hydrolysis of trifluoroacetyl and decarboxylation. Polar solvents were beneficial to the acylation and most of the Lewis acids tested showed good catalytic activities.