1-Alkyl-4-phenyl-6-alkoxy-1 H-quinazolin-2-ones: a novel series of potent calcium-sensing receptor antagonists

…, R Beerli, W Breitenstein, R Bouhelal…

Index: Widler, Leo; Altmann, Eva; Beerli, Rene; Breitenstein, Werner; Bouhelal, Rochdi; Buhl, Thomas; Gamse, Rainer; Gerspacher, Marc; Halleux, Christine; John, Markus R.; Lehmann, Hansjoerg; Kalb, Oskar; Kneissel, Michaela; Missbach, Martin; Mueller, Irene R.; Reidemeister, Sibylle; Renaud, Johanne; Taillardat, Agnes; Tommasi, Ruben; Weiler, Sven; Wolf, Romain M.; Seuwen, Klaus Journal of Medicinal Chemistry, 2010 , vol. 53, # 5 p. 2250 - 2263

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Citation Number: 25

Abstract

Parathyroid hormone (PTH) is an effective bone anabolic agent. However, only when administered by daily sc injections exposure of short duration is achieved, a prerequisite for an anabolic response. Instead of applying exogenous PTH, mobilization of endogenous stores of the hormone can be envisaged. The secretion of PTH stored in the parathyroid glands is mediated by a calcium sensing receptor (CaSR) a GPCR localized at the cell ...