Synthesis of compounds related to the anti-migraine drug eletriptan hydrobromide

SB Madasu, NA Vekariya, MH Kiran…

Index: Madasu, Suri Babu; Vekariya, Nagaji Ambabhai; Hari Kiran; Gupta, Badarinadh; Islam, Aminul; Douglas, Paul S.; Babu, Korupolu Raghu Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1400 - 1405

Full Text: HTML

Citation Number: 4

Abstract

Abstract Eletriptan hydrobromide (1) is a selective serotonin (5-HT 1) agonist, used for the acute treatment of the headache phase of migraine attacks. During the manufacture of eletriptan hydrobromide the formation of various impurities were observed and identified by LC–MS. To control the formation of these impurities during the preparation of active pharmaceutical ingredients, the structure of the impurities must be known. Major impurities ...