Development of practical rhodium phosphine catalysts for the hydrogenation of β-dehydroamino acid derivatives

…, A Börner, E Alberico, I Nieddu, S Gladiali…

Index: Enthaler, Stephan; Erre, Giulia; Junge, Kathrin; Holz, Jens; Boerner, Armin; Alberico, Elisabetta; Nieddu, Ilenia; Gladiali, Serafino; Beller, Matthias Organic Process Research and Development, 2007 , vol. 11, # 3 p. 568 - 577

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Citation Number: 36

Abstract

The rhodium-catalyzed asymmetric hydrogenation of various β-dehydroamino acid derivatives to give optically active β-amino acids has been examined. Chiral monodentate 4, 5-dihydro-3 H-dinaphthophosphepines, which are easily tuned and accessible in a multi-10- g scale, have been used as ligands. The enantioselectivity is largely dependent on the nature of the substituent at the phosphorous atom and on the structure of the substrate. ...

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