Journal of the American Chemical Society

The Preparation of Some Pyridazonyl Acids

JA King, FH McMillan

Index: King; McMillan Journal of the American Chemical Society, 1952 , vol. 74, p. 3222

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Citation Number: 12

Abstract

As a part of some exploratory work in the field of pyridazine chemistry we considered it desirable to study a series of 2-(3-pyridazonyl)-acetic acids and their derivatives, a description of the preparation of which forms the subject of the present paper. 6-Methyl-3- pyridazone (I) underwent ready alkylation on the nitrogen with ethyl bromoacetate in the presence of sodium ethoxide; the resultant ester (11) was hydrolyzed to the acid 111, as ...