Organic letters

Cascade Synthesis of Fenpiprane and Related Pharmaceuticals via Rhodium-Catalyzed Hydroaminomethylation

S Li, K Huang, J Zhang, W Wu, X Zhang

Index: Li, Shengkun; Huang, Kexuan; Zhang, Jiwen; Wu, Wenjun; Zhang, Xumu Organic Letters, 2013 , vol. 15, # 5 p. 1036 - 1039

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Citation Number: 12

Abstract

A novel rhodium catalytic system with Naphos as ligand was developed for an efficient hydroaminomethylation of 1, 1-diphenylethene under relatively mild conditions. This will allow for an atom-economic and environmentally benign synthesis of fenpiprane and related pharmaceuticals.

New synthetic route to pharmacologically active 1-(N, N-dialkylamino)-3, 3-diarylpropanes via rhodium-catalyzed hydroformylation of 1, 1-diarylethenes

[Botteghi; Cazzolato; Marchetti; Paganelli Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6612 - 6615]

Chemistry of dicationic electrophiles: Superacid-catalyzed reactions of amino acetals

[Klumpp, Douglas A; Sanchez Jr., Gregorio V; Aguirre, Sharon L; Zhang, Yun; de Leon, Sarah The Journal of organic chemistry, 2002 , vol. 67, # 14 p. 5028 - 5031]