N-Propynyl analogs of β-phenylethylidenehydrazines: synthesis and evaluation of effects on glycine, GABA, and monoamine oxidase

EM MacKenzie, A Fassihi, A Davood, QH Chen…

Index: MacKenzie, Erin M.; Fassihi, Afshin; Davood, Asghar; Chen, Qiao-Hong; Rauw, Gillian; Rauw, Gail; Knaus, Edward E.; Baker, Glen B. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 17 p. 8254 - 8263

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Citation Number: 3

Abstract

A group of β-phenylethylidenehydrazines possessing a variety of substituents (Me, OMe, Cl, F, and CF3) at the ortho-, meta-, or para-positions of the phenyl ring, in conjunction with either a N-bis-(2-propynyl) or a N-mono-(2-propynyl) moiety, were synthesized and compared to the novel neuroprotective drug β-phenylethylidenehydrazine (PEH) with regard to their ability to inhibit the enzymes GABA-transaminase (GABA-T) and monoamine ...