Synthesis of deuterium??labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its …

…, MS Bednarz, JJ Hangeland, SZ Ahmed…

Index: Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 3 p. 261 - 270

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Citation Number: 11

Abstract

Abstract D 5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d 5-Atorvastatin and d 5-atorvastatin lactone were prepared from d 5-aniline whereas their corresponding hydroxy metabolites were synthesized using ...