Journal of medicinal chemistry

Privileged scaffolds or promiscuous binders: a comparative study on rhodanines and related heterocycles in medicinal chemistry

T Mendgen, C Steuer, CD Klein

Index: Mendgen, Thomas; Steuer, Christian; Klein, Christian D. Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 743 - 753

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Citation Number: 117

Abstract

Rhodanines and related five-membered heterocycles with multiple heteroatoms have recently gained a reputation of being unselective compounds that appear as “frequent hitters” in screening campaigns and therefore have little value in drug discovery. However, this judgment appears to be based mostly on anecdotal evidence. Having identified various rhodanines and related compounds in screening campaigns, we decided to perform a ...