Scalable synthesis of the pink gypsy moth Lymantria mathura sex pheromone (–)-mathuralure

J Mowat, J Senior, B Kang…

Index: Mowat, Jeffrey; Senior, James; Kang, Baldip; Britton, Robert Canadian Journal of Chemistry, 2013 , vol. 91, # 3 p. 235 - 239

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Citation Number: 4

Abstract

Mathuralure (1) is the major sex pheromone component of the pink gypsy moth Lymantria mathura, a potentially devastating invasive species to North America. To support population monitoring of this moth, a gram-scale synthesis of (–)-mathuralure (1) was developed. This process relies on coupling an alkynyl lithium species with a chloroepoxide and provides access to the natural product in a 10% yield over 10 steps.