Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

B Büttelmann, JU Peters, S Ceccarelli…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 7 p. 1892 - 1897

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Citation Number: 10

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 6 In this regard, the mGlu5 receptor appears attractive as an anxiety target, because it offers good chemical tractability, the potential for high selectivity ... Some first exploratory chemistry around 1 revealed that the methyl substituent R (Fig ...