Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives

S Jha, JD Silversides, RW Boyle, SJ Archibald

Index: Jha, Sushil; Silversides, Jon D.; Boyle, Ross W.; Archibald, Stephen J. CrystEngComm, 2010 , vol. 12, # 6 p. 1730 - 1739

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Citation Number: 9

Abstract

Hydantoins have been known as medicinally active compounds since the 1940s and thiohydantoin derivatives are currently undergoing clinical trials as potent androgen receptor antagonist drugs. Control of solid state properties including the formation of drug polymorphs is important to the pharmaceutical industry, and frequently results from different H-bonded motifs. N–H thiohydantoins show formation of H-bonded arrays in the solid ...