SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity

…, DE Hruby, SR Tyavanagimatt, RD Allen, D Dai

Index: Burgeson, James R.; Moore, Amy L.; Boutilier, Jordan K.; Cerruti, Natasha R.; Gharaibeh, Dima N.; Lovejoy, Candace E.; Amberg, Sean M.; Hruby, Dennis E.; Tyavanagimatt, Shanthakumar R.; Allen III, Robert D.; Dai, Dongcheng Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 13 p. 4263 - 4272

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Citation Number: 13

Abstract

A series of acylthiourea derivatives were designed, synthesized, and evaluated for broad- spectrum antiviral activity with selected viruses from Poxviridae (vaccinia virus) and two different genera of the family Bunyaviridae (Rift Valley fever and La Crosse viruses). A compound selected from a library screen, compound 1, displayed submicromolar antiviral activity against both vaccinia virus (EC50= 0.25 μM) and La Crosse virus (EC50= 0.27 μM) ...