Efficient asymmetric (2+ 2) photocycloaddition leading to chiral cyclobutanes. Application to the total synthesis of (-)-grandisol

AI Meyers, SA Fleming

Index: Meyers, A. I.; Fleming, Steven A. Journal of the American Chemical Society, 1986 , vol. 108, # 2 p. 306 - 307

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Citation Number: 90

Abstract

Although asymmetric thermal (2+ 2) cycloadditions have been extensively described,' photocycloadditions using two olefin components have been only reported in a few cases and lack general synthetic utility2 as well as suffering from generally low yields. A number of (2+ 2) photocycloadditions, with high stereoselectivity, have been performed in an intramolecular fa~ hion,~ while others have elaborated chiral olefins in an intermolecular ...