Synthesis of L-selenocystine, L-[77 Se] selenocystine and L-tellurocystine

…, JN Schwarz, H Senn, M Salzmann, LA Silks

Index: Stocking, Emily M.; Schwarz, Jessie N.; Senn, Hans; Salzmann, Michael; Silks, Louis A. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 16 p. 2443 - 2447

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Citation Number: 57

Abstract

Synthetic routes for the synthesis of stable isotope labelled amino acids which contain either a selenium or a tellurium atom have been explored. L-Selenocystine, L-[77Se] selenocystine and L-tellurocystine have been constructed in four steps from commercially available methyl (2S)-2-[(tert-butoxycarbonyl) amino]-3-hydroxypropionate. The sequence of reactions has been successfully scaled up giving significant quantities of the chalcogen based amino ...