Tetrahedron letters

Studies directed towards the total synthesis of the antibiotic macrodiolide tartrolon: EPC synthesis of the protected seco acid

J Mulzer, M Berger

Index: Mulzer, Johann; Berger, Markus Tetrahedron Letters, 1998 , vol. 39, # 8 p. 803 - 806

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Citation Number: 20

Abstract

ABSTRACT: An efficient synthesis of the protected seco acid 2 of the antibiotic macrodiolide tartrolon 1 is described. Key steps are a substrate controlled aldol-reaction, a Johnson- Claisen rearrangement, and a Horner-Wadsworth-Emmons olefination with subsequent Corey-Bakshi-Shibata (CBS) reduction.

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