Bioorganic & medicinal chemistry letters

New trifluoromethyl quinolone derivatives: Synthesis and investigation of antimicrobial properties

SS Panda, SC Jain

Index: Panda, Siva S.; Jain, Subhash C. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3225 - 3229

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Citation Number: 7

Abstract

A series of quinolone derivatives, containing different heterocyclic amines were prepared. Synthesized compounds were evaluated for their in vitro antimicrobial activities against two Gram-positive bacteria, three Gram-negative bacteria as well as four fungi. All the derivatives showed good activity towards Gram-positive bacteria and less activity towards Gram-negative bacteria. They also showed moderate to comparable activity against ...