Chemistry–An Asian Journal

Hydrophobic Variations of N??Oxide Amphiphiles for Membrane Protein Manipulation: Importance of Non??hydrocarbon Groups in the Hydrophobic Portion

PS Chae, A Sadaf, SH Gellman

Index: Chae, Pil Seok; Sadaf, Aiman; Gellman, Samuel H. Chemistry - An Asian Journal, 2014 , vol. 9, # 1 p. 110 - 116

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Citation Number: 6

Abstract

Abstract Amphipathic agents called detergents serve as membrane-mimetic systems to maintain the native structures of membrane proteins during their manipulation. However, membrane proteins solubilized in conventional detergents tend to undergo denaturation and aggregation, necessitating the development of novel amphipathic agents with enhanced properties. Here we describe several new amphiphiles that contain an N-oxide group as ...