Kinetic resolution of (R, S)-pyrazolides containing substituents in the leaving pyrazole for increased lipase enantioselectivity

PY Wang, CH Wu, JF Ciou, AC Wu, SW Tsai

Index: Wang, Pei-Yun; Wu, Chia-Hui; Ciou, Jyun-Fen; Wu, An-Chi; Tsai, Shau-Wei Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 66, # 1-2 p. 113 - 119

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Citation Number: 12

Abstract

With hydrolysis of (R, S)-azolides in water-saturated methyl tert-butyl ether (MTBE) via Candida antarctica lipase B (CALB) as the model system,(R, S)-pyrazolides containing a leaving 3-, 4-or 3, 4-substituted-pyrazole moiety are selected as the best substrates for preparing various optically pure carboxylic acids containing an α-chiral center. Great improvements of enzyme activity for the (R)-enantiomers with excellent enantioselectivity ( ...