Optimization of asymmetric hydrogenation of 3-phenyl-3-butenoic acid catalyzed by rhodium (I)-4, 5-bis [(diphenylphosphino) methyl]-2, 2-dimethyldioxolane (DIOP)
K Yamamoto, K Ikeda, LK Yin
Index: Yamamoto, Keiji; Ikeda, Kiyoshi; Yin, Leong Kwai Journal of Organometallic Chemistry, 1989 , vol. 370, p. 319 - 332
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Abstract
Abstract Enantioselective, homogeneous hydrogenation of 3-phenyl-3-butenoic acid (1) has extensively been examined in the presence of the rhodium (I)/4, 5-bis [(diphenylphosphino) methyl]-2, 2-dimethyldioxolane (DIOP) catalyst systems. Optimization of the reaction conditions was undertaken mainly by controlling effects of added tertiary amines as well as solvent polarities on the enantio-selectivity of the product. The best asymmetric yield (85.1 ...
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