Inhibitors selective for HDAC6 in enzymes and cells

…, L Liu, AJ Lucke, SA Broomfield, MR Andrews…

Index: Gupta, Praveer K.; Reid, Robert C.; Liu, Ligong; Lucke, Andrew J.; Broomfield, Steve A.; Andrews, Melanie R.; Sweet, Matthew J.; Fairlie, David P. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7067 - 7070

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Citation Number: 22

Abstract

Acetylation of lysine residues in proteins is a reversible post-translational modification that impacts on many cellular processes, including signaling, RNA splicing, gene expression, protein stability and transport. 1 A recent proteomic analysis of three human cell lines identified 1750 nuclear and non-nuclear proteins modified by lysine acetylation at 3600 individual sites. 2 Lysine acetylation has been most extensively studied for histone proteins, where it regulates chromatin ...