ChemCatChem

Asymmetric Reduction of Cyclic Imines Catalyzed by a Whole??Cell Biocatalyst Containing an (S)??Imine Reductase

F Leipold, S Hussain, D Ghislieri, NJ Turner

Index: Leipold, Friedemann; Hussain, Shahed; Ghislieri, Diego; Turner, Nicholas J. ChemCatChem, 2013 , vol. 5, # 12 p. 3505 - 3508

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Citation Number: 29

Abstract

In view of the importance of chiral amines as building blocks for biologically active pharmaceutical drugs, considerable effort has been devoted to the development of asymmetric catalytic methods for their preparation. Notable advances have been made by using transition-metal catalysis,[1a] organocatalysis,[1b] and artificial transfer hydrogenases.[1c] However, biocatalytic approaches have emerged as being especially ...