One-Step Synthesis of 3-Aryl-and 3, 4-Diaryl-(1 H)-Pyrroles Using Tosylmethyl Isocyanide (TOSMIC)
ND Smith, D Huang, NDP Cosford
Index: Smith, Nicholas D.; Huang, Dehua; Cosford, Nicholas D. P. Organic Letters, 2002 , vol. 4, # 20 p. 3537 - 3539
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Citation Number: 50
Abstract
A one-step synthesis of 3-aryl and 3, 4-diaryl-(1 H)-pyrroles from TOSMIC and commercially available or readily synthesized arylalkenes is reported. Optimal conditions were found to be NaO t Bu in DMSO. The methodology was particularly efficient (yields> 65%) when electron poor aryl groups were attached to the alkene.
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