Mammalian alkaloids: Synthesis and O??methylation of (S)??and (R)??3′??hydroxycoclaurine and their N??methylated analogues with S??adenosyl??L??[methyl??14C] …
…, D Tadić, M Brzostowska, A Brossi, M Bell…
Index: He; Tadic; Brzostowska; Brossi; Bell; Creveling Helvetica Chimica Acta, 1991 , vol. 74, # 7 p. 1399 - 1411
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Abstract
Abstract O-Methylation of the optically active 3′-hydroxycoclaurines 3a and 3b and of the N- methylated analogs 5a, b with S-adenosyl-L-[methyl-14 C] methionine in presence of mammalian COMT was investigated in vitro. The N-unsubstituted (1S)-and (1R)-isomers 3a and 3b, respectively, afforded almost equal amounts of the corresponding N-norreticuline 4 and N-nororientaline 19, besides two unknown by-products (see Fig. and Table 1). The N- ...
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