Total syntheses and biological investigations of tamandarins A and B and tamandarin A analogs

…, DJ Richard, PS Portonovo, MM Joullie

Index: Liang; Richard; Portonovo; Joullie Journal of the American Chemical Society, 2001 , vol. 123, # 19 p. 4469 - 4474

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Citation Number: 52

Abstract

Tamandarins A (1) and B (2), two natural products similar in structure to didemnin B (3), were recently isolated from a Brazilian marine ascidian of the family Didemnidae. The cytotoxicity of 1 was reported to be somewhat more potent in vitro than that of 3 against various human cancer cell lines. The present account describes the first total syntheses of 1 and 2, and the syntheses of tamandarin A side chain analogues. The cytotoxicity data for ...

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