Characterization of an a beo-Taxane: Brevifoliol and Derivatives

…, C Soucy, N Towers, PJ Gunning, L Breau

Index: Tremblay, Steve; Soucy, Chantal; Towers, Neil; Gunning, Philip J.; Breau, Livain Journal of Natural Products, 2004 , vol. 67, # 5 p. 838 - 845

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Citation Number: 7

Abstract

Brevifoliol is a natural diterpene isolated from Taxus baccata Nutt. A series of brevifoliol 1 derivatives, 2-8 and 10, were prepared for characterization and semisynthesis purposes and included the introduction of acetyl, Troc, and TES groups at C-5 and C-13. Derivatives 16-20 of 5-acetylbrevifoliol 2 were obtained via esterification with cinnamic acid, with both 2 S-(-)- and 2 R-(+)-3-phenyllactic acid, and with N-benzoyl-(2'R, 3'S)-3'-phenylisoserine at C-13. ...