Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogs

M Cushman, D Nagarathnam, DL Burg…

Index: Cushman, Mark; Nagarathnam, Dhanapalan; Burg, Debra L.; Geahlen, Robert L. Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 798 - 806

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Citation Number: 183

Abstract

Treatment of o-hydroxyacetophenones 2a-e with excess lithium bis (trimethylsily1) amide followed by dim 1 carbonates gave alkyl 3-(2-hydroxyaryl)-3-oxopropanoates 3a-e. The latter substances were transformed through the reaction of their magnesium chelates with benzoyl chlorides into a series of 3-(alkoxycarbonyl)-2-arylflavones, which were subsequently elaborated into a variety of flavonoids. These compounds were tested for ...