4??[18F] fluorophenyl ureas via carbamate??4??nitrophenyl esters and 4??[18F] fluoroaniline

S Olma, J Ermert, HH Coenen

Index: Olma, Sebastian; Ermert, Johannes; Coenen, Heinz H. Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 12 p. 1037 - 1050

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Citation Number: 14

Abstract

Abstract Four different no carrier added (nca) 4-[18 F] fluorophenylurea derivatives are synthesized as model compounds via two alternative routes. In both cases carbamate-4- nitrophenylesters are used as intermediates. Either nca 4-[18 F] fluoroaniline reacts with carbamates of several amines, or the carbamate of nca 4-[18 F] fluoroaniline is formed at first and an amine is added subsequently to yield the urea derivative. The choice of the ...

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