Orthogonal Regioselective Synthesis of N??Alkyl??3??substituted Tetrahydroindazolones

J Kim, H Song, SB Park

Index: Kim, Jonghoon; Song, Heebum; Park, Seung Bum European Journal of Organic Chemistry, 2010 , # 20 p. 3815 - 3822

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Citation Number: 10

Abstract

Abstract A divergent strategy for the regioselective and orthogonal synthesis of complementary regioisomers of N-alkyl-3-substituted-tetrahydroindazolones 3 and 4 was achieved from Boc-protected alkylhydrazines 1. The robustness and substrate generality of this method were validated by synthesizing 3 and 4 through the intra-and intermolecular condensation of 1 with various 2-acylcyclohexane-1, 3-diones 2 and aldehydes, ...